Infectious Disease Models
Aragen Bioscience experts design and manage infectious disease programs that maximize a drug candidate’s probability of success. Our team’s extensive experience results in a thorough understanding infectious disease modelling, allowing our clients to creatively test compound activity, design new delivery mechanisms and explore novel vaccine strategies for a variety of infectious diseases.
Clostridium difficile (C. difficile) – Hamster
Clostridium difficile infection (CDI) can cause symptoms ranging from severe diarrhea to life-threatening inflammations of the colon. Although the infection can usually be controlled with antibiotics, virulent strains of C. difficile are now appearing that resist treatment with common medications.
- Established in vivo models of acute as well as relapse of C.difficile infection
- Our team is trained and experienced in handling this pathogenic organism
- Several dozen in vivo studies have been conducted cumulatively over the last eight years in the areas of therapeutic, prophylactic as well as vaccine models of this disease
Respiratory Syncytial Virus (RSV) – Mouse & Cotton Rat
RSV infection is the major cause of severe respiratory illness in infants and young children, as well as immune compromised individuals and the elderly. It causes a range of illnesses varying from mild infection to life-threatening bronchiolitis and respiratory failure. Rodent models for testing efficacy and safety in preclinical studies provide a critical component to the development of anti-RSV antibodies, small molecules and vaccines.
- We offer both mouse (BALB/c) and cotton rat (Sigmodon hispidus) RSV infection models
- A wide range of functional in vivo and ex vivo readouts are available to assess the efficacy of anti-RSV biologics and small molecules
- More than 60 pre-clinical studies in rodent models of RSV infection have been performed
Mouse Cytomegalovirus (mCMV)-Mouse
Human CMV (hCMV) is a major cause of birth defects in industrialized nations. While usually hCMV infection does not cause major illness in healthy people, it can be life-threatening for immunocompromised persons. Although CMV infection is species-specific, human and mouse CMV share much similarity at the genetic and nucleotide level. Moreover, the mouse CMV (mCMV) infection model shares many characteristics with human disease and can therefore be used to mimic human CMV infection in animals.
- Mouse (BALB/c) CMV infection model in normal and immunosuppressed animals
- A wide range of functional in vivo and ex vivo readouts are available to assess the efficacy of anti-CMV therapeutics