Cell Line Development

Aragen Bioscience offers stable cell line development (CLD) services with decades of experience delivering clinical stage & royalty free commercial Research Cell Banks (RCBs).

Expression Experience

We have gained experience with a broad range of molecules and continue to optimize the expression vectors, workflows and processes around stable CLD and protein expression. We’ve embodied this knowledge in our CLD solutions that combine proven CHO-GS and CHO-DG44 host cell lines, proprietary vectors and an innovative clone selection process to deliver high titers at every stage from Discovery to the Clinic.

Diverse Products

The ability to stably express proteins and produce the desired amount of product depends on a large number of factors. Depending on the project, only a few hundred micrograms of protein may be needed while other projects may require the manufacture of kilogram quantities of protein. Our CLD and expression platform supports a variety of life science and drug discovery applications:

  • Therapeutic CLD
  • Diagnostic reagents
  • Research tools and reagents
  • High throughput screening
  • Cell based assay tools
  • Crystallography
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Difficult to Express Proteins

Successfully expressing and purifying proteins can be difficult. Our team is often called upon to stably express and purify novel molecules that are challenging due to folding problems, toxicity to hosts, purification issues or any of a wide range of other problems. Our approach of continually optimizing and improving processes and assays enables our scientists to custom tailor the CLD process to your specific requirements.

Regulatory Friendly and Royalty Free

Our process has complete freedom to operate and comes with no clinical milestones or commercial royalties. In addition, the core technology has been reviewed many times over many years by the various regulatory agencies of the world. As such, this platform is well-documented and comes with very little regulatory risk.

What to Expect – Timelines and Titers

For protein expression projects requiring large amount of protein, the volumetric titer is critical to meeting the budget for manufacturing efforts. Our platform is very competitive with respect to its timeline to delivery and the titers obtained.

As every project is unique, we welcome the opportunity to discuss your stable protein expression needs. Contact us today.