Events 2018-09-02T01:33:20+00:00

Events

Future Events

Biotech Week Boston / Bioprocess International Conference

Boston, MA
September 4-7

Stand 613

Event Website

Past Events

The Bioprocessing Summit

Boston, MA
August 13-17

Don’t miss our poster!

Resolving Precipitation Issues of an Antibody-Fusion During Protein A Purification Through Flocculation

Rene Pagila, Michelle Stroud and Tim Myles

Abstract: Two distinct antibody-fusion proteins that share a common fusion partner have the propensity to precipitate upon elution during Protein A purification. In addition, further precipitation occurs upon pH neutralization of the pH 3 eluted protein. After removing the precipitate, the remaining soluble antibody-fusion was highly aggregated when assessed by analytical SEC. A flocculation strategy was employed on clarified cell culture harvests to resolve the precipitation issues.

Event Website

IPF Summit

San Francisco, CA
August 20-22

Don’t miss our poster!

Bioanalytical and Functional Characterization of Bleomycin-Induced Pulmonary Fibrosis Model in Mice

Jong Seok Kang, Rashmi Munshi, Donovan Unks, Malavika Ghosh

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease that causes scarring and thickening of the lung tissue leading to respiratory failure. Despite the approval of Pirfenidone and Nintedanib in multiple countries for the treatment of IPF, lung fibrosis remains a major unmet medical need. Bleomycin-induced pulmonary fibrosis has been a useful pre-clinical model in several species and is most prevalent in rodent models to evaluate potential prophylactic and therapeutic drugs for IPF. Aragen Bioscience has run more than three hundred studies over the span of a decade for our numerous clients resulting in pre-clinical data for multiple INDs. Our extensive experience with this model has led to a proven track record of highly reproducible and successful preclinical studies. Bioanalytical and functional analysis further demonstrates the relevance and reliability of this model for the evaluation of anti-fibrotic agents.

Event Website

Webinar: High-Throughput Developability Assessment of Therapeutic Antibody Candidates in Discovery Stage

Broadcast Date: Wednesday, June 20, 2018
Time: 8 am PT, 11 am ET, 17:00 CEST

The stability of a candidate drug-protein is critical to the success or failure of its development as a viable drug. Low stability could adversely impact production consistency, shipping and handling excursions, and long-term storage. Developability assessments are becoming an increasingly important criterion to mitigate this risk. The conventional approach is to perform the developability assessment on the final few shortlisted candidates at the mid-to-late stage of drug development.

At Aragen, we have moved the developability assessment into the discovery phase during antibody screening, accelerating the candidate selection process. Integration of the Uncle platform into our process was essential for early assessments due to its small sample requirements and rapid analysis time. In this study, we show that humanized antibody candidates of a murine monoclonal antibody differ in their thermal melting and thermal aggregation profiles due to differences in the stability of the Fab domain (that carries the target binding residues) because of the humanization process. Destabilization of the Fab domain or lower aggregation onset can lead to problems later during production, shipment, or storage. Assessment of thermal stability and aggregation potential can be an important tool for early selection of viable drug candidates. Analysis during antibody screening (discovery stage) and clone selection (early process development stage) can significantly reduce the time and cost of downstream manufacturing.

This presentation by Aragen Bioscience is sponsored by Unchained Labs and hosted by Genetic Engineering News. A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelist.

Event Registraton

Cell Line Development & Engineering

San Francisco, CA
June 4-7

BIO (with GVK BIO)

Boston, MA
June 4-7
Booth 475

Event Website

BIO KOREA
Seoul, Korea
May 9-11
Booth M44

Event Website

Join us for our presentation:
May 9, 16:30 – 17:00
Room 301A

Event Website

PEGS Boston
April 30 – May 4
Booth 516

Event Website

BPI West
March 19-22, 2018
San Francisco, CA
Booth #414

Event Page

Molecular Med Tri-Con
February 11-16, 2018
San Francisco, CA
Booth #201

Event Website


PepTalk: The Protein Science Week
January 8-12, 2018
San Diego, CA
Booth #413

Event Page


Antibody Engineering and Therapeutics
December 11-15, 2017
San Diego, CA
Booth #308

Event Page

BioProcess International Conference and Exhibition
September 25-28, 2017
Boston, MA
Booth# 1328

Don’t miss our poster:

Comparing Bioreactor Antibody Titer Measurements Obtained in Real Time to Other Antibody Measuring Techniques

Event Page


MassBio CRO/CMO Symposium 
September 28, 2017
Boston, MA

Event Website


Idiopathic Pulmonary Fibrosis Summit
August 21-23, 2017
Boston, MA

Download Poster Presentation: A Highly Reproducible In Vivo Model for Bleomycin-Induced Lung Fibrosis in Mice to Evaluate Drugs for the Treatment of Idiopathic Pulmonary Fibrosis

Event website


BioProcessing Summit
August 21-24, 2017
Boston, MA
Booth 503

Download Poster Presentation: A Novel Approach to Real Time Monitoring of Antibody Titer in a Fed-Batch Bioreactor Run

Event website


Drug Discovery & Therapy World Congress 2017
July 10-13, 2017
Boston, MA

Event website


2017 BIO International Convention
June 19-22, 2017
San Diego, CA

Event website


PEGS Boston
May 1-5, 2017
Boston, MA
Booth 329

Join us at the poster sessions for:

The UNcle system for thermodynamic and aggregation profiling of antibodies and Fc-fusions in a CRO setting

A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

Event website


Sourcing Strategies for Pre-Clinical Contract Research Services
A CRISPR Therapeutics / Aragen Case Study
MassBio Seminar Luncheon
April 27, 2017
Cambridge, MA

We’ve recently joined MassBio and to celebrate we’re holding a luncheon seminar on April 27 at the MassBio offices in Cambridge. The event is free but space is limited so register today and we’ll keep you in the loop.

Event page


Bioprocess International West
February 27 – March 2
Booth 414
San Francisco, CA

Event website


Molecular Medicine Tri-Con 2017
February 19-24, 2017
Booth 718
San Francisco, CA

Poster Presentations:

A Highly Reproducible In Vivo Model for Bleomycin-Induced Lung Fibrosis in Mice to Evaluate Drugs for the Treatment of Idiopathic Pulmonary Fibrosis

In Vivo Models and In Vitro Assays for Human RSV Infection –
Pre-Clinical Antibody, Small Molecule and Vaccine Development

Event website


BioAsia 2017
February 6-8, 2017
Hyderabad (in association with GVK Biosciences)

Event website


9th Annual Biotech Showcase
January 9-11, 2017
San Francisco, CA

Event website


PepTalk
January 9-13, 2017
Booth 513
San Diego, CA

Visit us at the poster session:

Expressing an Antibody with an Engineered Fc-Domain that Shows Enhanced Antibody-Mediated Cellular Cytotoxicity Properties.

Tuesday
3:45 – 4:30pm

Wednesday
10:05 – 10:50am
3:35 – 4:30pm
6:20 – 7:20pm

Event website


Antibody Engineering
December 11-12
Booth #404
San Diego, CA

Event website


LakePharma Protein Engineering Symposium
October 7
South San Francisco, CA

Visit our booth and poster session.

Event website


BioProcess International
October 4-7
Booth #517
Boston, MA

Event website