Technical Resources

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Aragen Brochure

Aragen Fibrosis Services

Aragen Cell Line Development Services

Aragen Idea to IND – Biologics Developability

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Technical Summary of Fibrosis Models

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A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

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An Integrated Stepwise Approach to Developability Assessment of Therapeutic Antibody Candidates from Discovery to Development

Resolving Precipitation Issues of an Antibody-Fusion During Protein A Purification Through Flocculation

Biological and Functional Characterization of a Bleomycin-Induced Pulmonary Fibrosis Model in Mice

A Novel Approach to Real Time Monitoring of Antibody Titer in a Fed-Batch Bioreactor Run

In Vivo Model and Ex Vivo Analysis for Murine Cytomegalovirus in BALB/c Mice

The UNcle System for Thermostability and Aggregation Profiling of Antibodies and Fc-Fusions in a CRO Setting

A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

A Highly Reproducible In Vivo Model for Bleomycin-Induced Lung Fibrosis in Mice to Evaluate Drugs for the Treatment of Idiopathic Pulmonary Fibrosis

Custom Monoclonal Antibodies for Therapeutic and Diagnostic Targets – A One-Stop-Shop for Pre-Clinical Antibody Research

In Vivo Models and In Vitro Assays for Human RSV Infection – Pre-Clinical Antibody, Small Molecule and Vaccine Development

A Comprehensive Portfolio of In Vitro and In Vivo Assays for the Characterization and Development of Novel Anti-TNFa Biologics

Optimizing Effector Functions of Therapeutic Antibodies & Biosimilars Using a Diverse Portfolio of Biophysical and Functional Cell-Based Assays

Summary of ADCC and CDC data presented at the American Society of Hematology conference

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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment. Nature Medicine 16, 1009–1017 (2010). The in-life portion of this study was performed at Aragen Bioscience.

Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients The Journal of Immunology, November 15, 2009 vol. 183 no. 10 6338-6345

Strategies for Rapid Production of Therapeutic Proteins in Mammalian Cells

A High Yielding, CHO-K1-Based Transient Transfection System: Rapid Production for Therapeutic Protein Development

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Comprehensive Solutions for the Biopharmaceutical Industry

An introduction to our services from concept to IND. 17 minutes

Using Activity Measurements to Drive Clone Selection

A case study highlighting the creation of a stable CHO cell line as well as the development of a scalable purification scheme suitable for cGMP production. The challenge of identifying and separating an inactive form of the protein of interest will be discussed. 15 minutes