Protein Analytics

Aragen Bioscience, a leading CRO, offers a range of analytical methods utilizing multiple assay platforms that be used to characterize a broad range of proteins expressed and purified by various methods:

  • Protein activity
    • Binding affinity (FortéBio Octet® RED96 System)
    • Enzyme activity
    • Cell-based assays
    • In vivo testing
  • Aggregation status
    • SDS-PAGE
    • SEC-HPLC
    • Optical density
  • Protein stability (Unchained Labs Uncle)
    • Tm & Tagg
    • ΔG
    • Isothermal stability
    • Thermal recovery
    • Sizing & polydispersity
    • Sizing with thermal ramp
    • B22 & kD
    • Viscosity
  • Protein integrity and structure
      • SEC-HPLC
      • SDS-PAGE
      • N-glycan analysis
      • Western Blot

  • Protein mass (Agilent HPLC-CHIP/QTOF)
      • Accurate mass: proteins, protein-drug conjugates
      • Peptide and Glycan mapping
      • Determination of post-translations modifications either in known or unknown samples.
      • Standard COAs

Our team will work closely with you from concept through delivery. Together, we’ll develop a set of project deliverables tailored to your specifications of scale, purity, activity and other analytical characteristics on a timeline that meets your needs. The protein science group works in close collaboration with Aragen’s cell biology and in vivo teams to provide a tightly integrated solution for your development needs.

Ready to take the next step?