Antibody Production & Characterization
The initial screening of hybridomas enables the identification of panels of monoclonal antibodies of interest. The further triage of these panels to identify those exhibiting specific characteristics, such as binding affinity, species- and family member cross reactivity and other qualities, requires significantly more protein than that is available in the small small scale cultures of the initial screening stages.
With expertise in the multiple methods of scaling up antibody production, our team will help guide you based on your needs. The production of the monoclonal antibodies of interest can be performed either by the scale up of the hybridomas themselves or via the cloning and expression of the monoclonal antibody using recombinant techniques. If a recombinant method is chosen, we may suggest to isotype switch the antibody or generate a human-mouse chimeric molecule should a human Fc domain be required for further efficacy evaluations. Our bio-production capabilities will meet your needs from microgram- to gram scale.
We take a wholistic approach to monoclonal antibody characterization, selecting analytical techniques and assays that best meet your needs, which may include various biophysical and molecular techniques as well as efficacy measurements.
We think you’ll find our team’s knowledge and expertise ready to tackle even the most challenging development project. Ready to learn more?