Careers2019-01-18T22:51:27+00:00

Careers

Scientist

We are seeking a motivated professional to join the Protein Sciences Division supporting protein analytics for protein bioproduction, process development, hybridoma antibody discovery and cell line development. Experiments will include protein formulation and stability studies, support of hybridoma campaigns with off rate ranking, binning, and epitope mapping.  Experience in protein and antibody ligand and enzyme kinetics is essential.

Requirements for the position include:

  • Education: A Ph.D in Biology or Biochemistry and at least 1-3 years of post-graduate experience in a professional environment. Intuitive knowledge and technical excellence in protein kinetics and biophysical characterization of proteins.
  • Ability to drive strategies and problem solve for biochemical and biophysical characterization of a diverse range of proteins from many different customers.
  • Good communication skills and the ability to work well as a member of a team is required.Excellent oral and written communication skills
  • Proficiency in Word, Excel, PowerPoint and data analysis are expected
  • Experience in enzymology (chromogenic/fluorogenic assays), Ligand binding kinetics (ForteBio/Biacore),
  • Formulation and stability assays with experience in DSC, DSF/UNCLE™, SLS and DLS, ELISA and western blot analysis including assay qualification,
  • Mass Spectrometry and SEC-MALs (optional),
  • Cell based potency assays including the AlphaLISA format (optional).

WORKING CONDITIONS:

  • Laboratory setting
  • Able to lift up to 30 lbs.
  • Based on project needs working schedule may include some after-hours or weekend duties

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Scientist/Senior Research Associate/Research Associate

We are seeking a Scientist or experienced Research Associate who under the direction of a senior scientist or director, the successful candidate will be responsible for the execution of all technical tasks and data analysis associated with preclinical research projects.  In addition, depending on the position, it will be necessary to manage research associates who are executing preclinical assay projects for clients. The candidate will be an innovative, independent and motivated professional. He or she will have significant and broad experience in combinations of the following areas:  maintenance of cell cultures, inventory of samples originating from the preclinical projects, cell based assays, ELISA. The candidate will be able to perform analytical assays used using ELISA, Western Blot and related techniques. The candidate will have experience with troubleshooting assays and should be capable of data analysis, data presentation and interested in learning new areas of research.

Requirements for the position include:

  • BS, MS, Ph.D. in any discipline of Biology or chemical engineering
  • Experience in cell culture within a drug discovery organization or a CRO
  • Deep knowledge of functional analysis using different analytical techniques
  • Working in an environment of team work and collaboration
  • Excellent communication and interpersonal skills and proven success working in matrix environments

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Animal Research Technician (Part Time)

We are currently seeking an experienced animal technician for our in vivo research projects. He/She will perform duties involving the daily care of research animals for experimental purposes, which includes daily health monitoring (taking body weight measurement), collecting other in vivo data (e.g., tumor measurement), dosing of animals (ip, iv, sc, and po), and collecting the organ samples (bleeding i.e., tail or retro-orbital bleeding, or cardiac bleeding and extracting organ tissues). All work will involve the direct handling of laboratory mice with a potential work with rats and other rodents. The candidate is also required to work in a barrier facility and wearing proper PPE. Interested candidates should have several years of pertinent experience in a small to medium scale animal care facility and meet the following requirements:

  • High school degree or equivalent, college degree preferred.
  • Hands-on experience with handling laboratory rodents.
  • Proficient with compound dosing and collection of samples for PK/PD
  • Competent at entering data onto a laptop computer.
  • Skill and knowledge to apply principles of sanitizing and disinfecting cages 
in compliance with AAALAC standards.
  • Availability to work variable schedule including weekends and holidays.
  • Experience in surgical techniques and/or in vivo disease models is highly
  • AALAS certification (ALAT or higher) preferred.
  • Accurate record keeping and troubleshooting skills
  • Self-motivated, flexible, and willing to meet strict time lines
  • Strong interpersonal communication skills
  • Ability to work in a fast paced, goal oriented, team-based environment 
Aragen is an equal opportunity employer. We offer a challenging work environment with excellent salary and benefits.

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Research Associate/Senior Research Associate

Protein Purification and Analytics

We are seeking a motivated professional with experience in the purification and characterization of recombinant proteins. A strong working knowledge of downstream process development and final product characterization is required. A broad knowledge of protein chemistry and enzymology is desired. The successful candidate will demonstrate the ability to diligently and expertly handle multiple projects and tasks simultaneously and generate accurate documentation.

Requirements for the position include:

  • BS or MS in biochemistry or related field or comparable experience.
  • At least five years of relevant industry experience.
  • Has routinely performed SDS-PAGE, IEF-PAGE, Native-PAGE, Western Blot, colorimetric protein quantitation assays, ELISA, chromogenic activity assays and UV spectrophotometry.
  • Hands-on experience on the use of diverse chromatographic resins, on column packing, on ultrafiltraion and diafiltration (UF/DF), on cell culture harvest clarification and on sterile techniques.
  • Program, operate, maintain and troubleshoot equipment such as AKTA purification systems such as Purifier and Pure, AKTA flux cross flow filtration system and Agilent 1100 HPLC.
  • Familiarity on operating capillary electrophoresis and mass spec equipment a plus.
  • Good oral and written communication skills.
  • Able to maintain detailed written records.
  • Ability to work independently as a member of a matrixed team in a fast paced laboratory environment.
  • Managerial experience and familiarity with cGMPs are highly desired.

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Scientist; Cell Line Development

We are seeking a Scientist who under the direction of a senior scientist or director will be responsible for the execution of all technical tasks and data analysis associated with cell line development projects.  In addition, the position will be necessary to manage research associates who are executing cell line development and process development projects for clients. The candidate will be an innovative, independent and motivated professional. He or she will have significant and broad experience in combinations of the following areas:  stable and transient expression of proteins and antibodies, development of recombinant cell lines, early-stage upstream process development and production of proteins and monoclonal antibodies in shake flasks and bench-scale bioreactors. The candidate will be able to perform analytical assays used to characterize expressed proteins and antibodies including ELISA, Western Blot, BLI measurement. The candidate will have experience with troubleshooting protein expression, cell culture and assay related problems.

POSITION DUTIES AND RESPONSIBILTIES:

  • Experience in enzymology (Chromogenic/Fuorogenic assays),
  • Ligand binding kinetics (ForteBio/Biacore),
  • Formulation and stability assays with experience in DSC, DSF/UNCLE™, SLS and DLS,
  • ELISA and western blot analysis including assay qualification,
  • Mass Spectrometry and SEC-MALs (optional),
  • Cell based potency assays including the AlphaLISA format (optional).

REQUIREMENTS:

  • BS, MS, Ph.D. in any discipline of Biology or chemical engineering
  • Experience in mammalian cell line development within a drug discovery organization or a CRO
  • Deep knowledge of mammalian cell protein expression and upstream process development across different platforms.
  • Deep and current knowledge of bioreactor design, function and maintenance. Direct involvement in a GMP process or transfer to a GMP facility.
  • Excellent communication and interpersonal skills and proven success working in matrix environments

Apply Now


Aragen Bioscience provides a challenging work environment in which talented employees expand their technical skills and scientific knowledge and contribute directly to the ongoing success of the organization. The Company is located in Morgan Hill, California, at the south end of the Silicon Valley. We offer excellent salary and benefits. Aragen is an equal opportunity employer.