In vitro 2017-06-27T06:06:57+00:00

In Vitro Efficacy Testing Services

The in vitro testing of product candidates can vary tremendously depending on the nature of the molecule, the biology being investigated and the overall requirements for throughput and yield. This important step requires a team of dedicated scientists who will work with you to develop and implement assays suitable for your specific research requirements.

In Vitro Efficacy Services

At Aragen Bioscience, we offer a diverse portfolio of cell-based and biophysical  assays that enable the development and characterization of new therapeutics based on both the physical characterization of the protein (expression, size, weight, binding) as well as the biological activity in mammalian cells and ultimately in animals.

Cell Based Assay Services

Our cell biology team has extensive experience developing cell based assays for determining mechanisms of action, evaluating potential therapeutics, and screening small libraries of compounds. We offer assays in a variety of cell types including primary cells and/or immortalized cell lines of interest to meet the specific needs of our clients. Our cell based assay service portfolio includes:

TypeAssay Type

Immunology
  • Immunophenotyping
  • Lymphocyte sybset analysis
  • Toxicity assays—ADCC, ADCP, CDC
  • Fc receptor binding
  • Mixed lymphocyte reactions
  • Treg, NK cell, macrophage assays
  • Multiplex cytokiine profiling
  • ELISpot
  • Immune function assays

Oncology
  • Apoptosis
  • Cell proliferation (BrdU, MTT)
  • Antibody-Target affinity

Signaling
  • Phospho-flow
  • Reporter Gene Assays
  • Migration Assays

Primary Cell
  • Imminology Assays
  • HUVEC, HMVEC, VSMC, RPTEC

Other
  • Genotyping
  • siRNA Testing
  • Custom Assays

 

Protein Analytics

The Protein Science team provides a range of analytical methods using multiple assay platforms that can be used to characterize a broad range of therapeutic, diagnostic or reagent-grade proteins.

>>Learn more about our protein analytic service offering

Custom Assay Development

Our in vitro services can be applied to both large and molecule therapeutics. As each molecule and mechanism of action is unique, Aragen Bioscience understands the need for flexibility and attention to detail in all of its services. If you don’t see the assay you need, bring your custom projects to us and our team of experienced assay development scientists will create a novel assay that meets your research requirements.

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