Infectious Disease Models (BSL-2)

• Respiratory Syncytial Virus (RSV) in mice and cotton rats
• Clostriduim Difficile associated diarrhea model in hamsters and mice
• Cytomegalovirus (CMV) in mice

Knock-outs and Transgenics 

• Design and construction of genetic constructs
• Genotyping, breeding and strain maintenance
• Genetic monitoring of transgenic colonies

Customized Animal Model Development

• Focus on chronic and immune diseases
• New Cancer Models
• Animal models for specific diseases
• Neurology Disease Models
• Diabetes and Obesity Disease Models
• Focus on chronic and immune diseases
• Respiratory Diseases (Asthma)
• Musculo-skeletal syndrome (MSS) model in rats 

New Cancer Models

• Lung metastasis model
• Orthotopic cancer models
  • Breast
  • Lung
  • Pancreas
  • Kidney
  • Gastro intestinal
  • Intra-splenic

Stem Cell Research

• Supply of feeder cells
• Differentiation of ES cells
• Custom research services with ES cells
• Injection of ES cells into organs of interest

Ascites Production / Purification

• Cells can be supplied to us frozen or as growing cultures. Cells are expanded, harvested, counted, washed in serum-free medium, and resuspended at the appropriate density. Pristane-primed animals are inoculated and then monitored daily for ascites production. Promptly following collection, ascites are centrifuged and frozen. Upon the completion of the production run, the harvests are pooled, thawed and reclarified. A sample of ascites is removed and assesed for antibody titer

Microsurgery

• Implantation of tumor cells, gels or other materials
• Orthotopic implantations, intra-organ injections, survival surgeries

Histopathology

• Formalin infusion of whole animal
• Selected organ harvesting/formalin storage
• Block setting, H&E staining
• Immunohistochemistry (IHC)
• IHC Certified Antibodies

RNAi Studies

• RNA interference studies in ES, primary and immortalized cell line

Regenerative Medicine

• Excisional and incisional models in mice
• Full-thickness dermal wound healing model in diabetic, Obese db/db mice
• Cartilage repair model of Osteochondral Defects in Athymic Rats using matrix encapuslated ES-Cells